Long-Term Conditioning of a Donor Heart by Autoperfusion

The aim of research was to study parameters homeostasis and conditions for stable operation the autoperfused heart-lung complex ex vivo.Materials methods. A series acute experiments (n-3) carried out create a functioning vivo. large mammal (mini-pig weighed 20-30 kg) used as an experimental model. During experiment, invasive blood pressure in aortic root, pulmonary artery, central venous pressure, temperature left ventricle heart, gas composition arterial (in root) flowing from coronary sinus monitored.Results. evidenced fundamental possibility isolated vivo functioning. 4-hours autoperfusion "heart-lung" complex, hemodynamics, biochemical remained within reference values.Conclusion. analysis literature data results on laboratory animals allow us state that can be successfully option safe long-term conditioning donor heart. This technique improve heart transplantation with prolonged ischemia organ. Extending survival will significantly expand geography bases, reducing ischemic period minimum.